Bioengineering

Bioengineering
http://bioe.rice.edu/
BioScience Research Collaborative
713-348-5869

K. Jane Grande-Allen
Department Chair
grande@rice.edu

Robert Raphael
Director of Graduate Studies
rraphael@rice.edu

Renata Ramos
Director of Undergraduate Studies
renata.ramos@rice.edu

To train the next generation of leaders in bioengineering, Rice's Bioengineering department has created an innovative teaching program that transcends boundaries between bioengineering, basic science, and clinical medicine, integrating the academic, industrial, and societal perspectives. Our hands-on approach to education is supported by a long standing tradition of cross-disciplinary research and education.

The Rice Bioengineering program is a comprehensive training program that provides student with:

  • A fundamental understanding of the life and medical sciences. 
  • Advanced analytical and engineering capabilities. 
  • Translational research capability for transferring biotechnical advances from bench to bedside.

With this educational background, graduates will be well prepared to participate in independent or collaborative research and development endeavors in industry or academia.

Graduate programs in bioengineering offer concentrations in areas such as biomedical imaging and diagnostics, cellular and biomolecular engineering, computational and theoretical bioengineering, biomaterials and drug delivery and biomaterials, systems and synthetic biology, and tissue engineering and biomechanics. Research areas include biomechanical engineering, biological systems modeling, bioinformatics, cellular and molecular engineering, controlled release technologies, metabolic engineering, spectroscopy, statistical mechanics, systems engineering and instrumentation, thrombosis, tissue engineering, and transport processes.

Master's Programs

Doctoral Program

Coordinated Programs

Chair

K. Jane Grande-Allen

Professors

Gang Bao
Michael Deem
Rebekah Drezek
Jane Grande-Allen
Herbert Levine
Jianpeng Ma
Antonios Mikos
Rebecca Richards-Kortum
Ka-Yiu San

Associate Professors

Michael Diehl
Oleg Igoshin
Robert Raphael
Junghae Suh
Jeffrey Tabor
Tomasz Tkaczyk

Assistant Professors

Jordan Miller
Omid Veiseh
David W. Zhang

Professors in the Practice

Z. Maria Oden

Lecturers

Bilal Ghosn
Renata Ramos
Eric Richardson

Professors, Joint Appointments

John Clark
Fathi Ghorbel
Ramon Gonzalez
Naomi Halas
Jeffrey Hartgerink
Lydia Kavaraki
Marek Kimmel
Marie Lynn Miranda
Frank Tittel
Kyriacos Zygourakis

Associate Professors, Joint Appointments

Matthew Bennett
Ching-Hwa Kiang
Angel A. Marti
Laura Segatori
Jonathan Silberg

Assistant Professors, Joint Appointments

Caleb Kemere
Jacob Robinson
Aryeh Warmflash

Adjunct Professors

Maria Elena Bottazzi
William Brownell
Ill-Min Chung
William Cohn
Mary Dickinson
Rena D'Souza
Charles Fraser
Ann M. Gillenwater
Peter J. Hotez
Ragha Kalluri
Anirbam Maitra
John McDevitt
David R. Piwnica-Worms
Eric Richardson
Robert C. Robbins
Rodigo Ruano
Jacqueline Shanks
Andrew Sikkora
Karen Storthz
Mark Wong
Samuel Miao-Sin Wu

Adjunct Associate Professors

Catherine Ambrose
Sharmila Anandasabapathy
Elizabeth Cosgriff-Hernandez
Miguel Cruz
M. Waleed Gaber
Stephen H. Little
Joseph Ludwig
Andrew Sikora
Konstantin Sokolov

Adjunct Assistant Professors

Aviva Presser Aiden
Aaron Foster
Michael J. Heffernan
Kurt Kasper
Steven Millward
Medhi Razavi
Niki Zacharias Millward

For Rice University degree-granting programs:
To view the list of official course offerings, please see Rice’s Course Catalog
To view the most recent semester’s course schedule, please see Rice's Course Schedule

Bioengineering (BIOE)

BIOE 202 - CAREERS IN BIOENGINEERING

Short Title: CAREERS IN BIOENGINEERING

Department: Bioengineering

Grade Mode: Satisfactory/Unsatisfactory

Course Type: Seminar

Credit Hour: 1

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Lower-Level

Description: This seminar is suitable for freshman, sophomores, and non-majors. A series of guest lectures will introduce students to a variety of career options in bioengineering. Students will participate in at least one field trip to an industry partner or hospital to learn more about careers in bioengineering.

BIOE 252 - BIOENGINEERING FUNDAMENTALS

Short Title: BIOENGINEERING FUNDAMENTALS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Lower-Level

Prerequisite(s): MATH 101 and MATH 102 and MATH 211 (may be taken concurrently) and CHEM 122 and CAAM 210 and (PHYS 101 or PHYS 125 or PHYS 111) and (PHYS 102 or PHYS 126 or PHYS 112)

Description: Introduction to material, energy, charge, and momentum balances in biological systems. Steady state and transient conservation equations for mass, energy, charge and momentum will be derived and applied using basic mathematical principles, physical laws, stoichiometry, and thermodynamic properties. Problem based learning groups will solve open-ended problems. Required for students intending to major in bioengineering. MATH 211 is a concurrent prerequisite and may be taken the same semester.

BIOE 302 - SYSTEMS PHYSIOLOGY

Short Title: SYSTEMS PHYSIOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOC 201 and (PHYS 101 and PHYS 102) or (PHYS 125 and PHYS 126)

Description: This course will teach the fundamentals of human physiology with a specific focus on the nervous, cardiovascular, respiratory, and urinary systems. Basic introductory engineering principles will be applied to the study of physiological systems. The course is aimed to be accessible to students with non-engineering backgrounds. Students may receive credit for only one of BIOE 302, BIOE 322, and BIOC 332. Cross-list: BIOC 332. Mutually Exclusive: Credit cannot be earned for BIOE 302 and BIOE 322.

BIOE 307 - SYSTEMS BIOLOGY OF BLOOD VESSELS

Short Title: SYS BIOLOGY OF BLOOD VESSELS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 252

Description: How blood vessels respond to hypoxia is a process critical to the progression of many diseases and conditions including cardiovascular disease, cancer, cerebrovascular disease, diabetes, obesity and arthritis. Physiological processes such as exercise, aging, and wound healing also depend on hypoxia-induced microvessel changes. This course introduces engineering concepts of hypoxic response, angiogenesis, and capillary remodeling - from the effects at the intracellular level to the whole body. Topics covered include computational systems biology modeling of hypoxia and angiogenesis, the use of angiogenesis in tissue engineering and regenerative medicine, imaging of blood vessel dynamics, capillaries of the brain, and the design of new blood vessels. Graduate/Undergraduate Equivalency: BIOE 507. Mutually Exclusive: Credit cannot be earned for BIOE 307 and BIOE 507.

BIOE 320 - SYSTEMS PHYSIOLOGY LAB MODULE

Short Title: SYSTEMS PHYSIOLOGY LAB MODULE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hour: 1

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 252 and (BIOS 332 or BIOE 322 (may be taken concurrently) or BIOC 332 (may be taken concurrently))

Description: Exploration of physiologic systems through measurement of biologic signals. EEG, ECG, EMG pulmonary function tests, etc. are performed and analyzed. Students will explore physiologic concepts through computer simulations, data collection, and analysis. Enrollment in or completion of BIOE 322/BIOC 332 is expected and maybe taken the same semester as BIOE 320. For students intending to major in Bioengineering. Instructor Permission Required.

BIOE 321 - CELLULAR ENGINEERING

Short Title: CELLULAR ENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 252

Description: Introduction to engineering principles and modeling regulation and circuitry at the cellular level. Topics include genetic metabolic networks and cell surface interactions.

BIOE 322 - FUNDAMENTALS OF SYSTEMS PHYSIOLOGY

Short Title: FUND OF SYSTEMS PHYSIOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 252 and MATH 211

Description: This course will teach the fundamentals of human physiology from an engineering perspective, with specific focus on the nervous, cardiovascular, respiratory and urinary systems. Lectures, assignments and exams will be quantitative and will introduce engineering principles, such as conservation of mass and energy, controls and system analysis, thermodynamics and mass transport, and apply them to the study of physiologic systems. This course is limited to undergraduates. Students may receive credit for only one of BIOE 302, BIOE 322, and BIOC 332 Mutually Exclusive: Credit cannot be earned for BIOE 322 and BIOC 332/BIOE 302.

BIOE 330 - BIOREACTION ENGINEERING

Short Title: BIOREACTION ENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 252 and (BIOC 201 or BIOS 201)

Description: Application of engineering principles to biological processes. Mathematical and experimental techniques for quantitative descriptions of enzyme kinetics, metabolic and genetic networks, cell growth kinetics, bioreactor design and operation.

BIOE 332 - BIOENGINEERING THERMODYNAMICS

Short Title: BIOENGINEERING THERMODYNAMICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 252 and MATH 212

Description: This course provides a mathematically rigorous and quantitative coverage of the fundamentals of thermodynamics with applications drawn from contemporary bioengineering problems. Fundamental topics will include the Zeroth, First and Second Law, Entropy Inequality, Gibbs and Helmholtz Free Energies, The Third Law, Maxwell Relations, chemical potential, equilibrium, phase transitions, solution thermodynamics, protein-ligand binding and statistical mechanics. Advanced topics will include transcription factor-DNA binding, nucleic acid hybridization, translation initiation and genetic circuits. The course will cover the role that thermodynamics plays in molecular engineering and synthetic biology.

BIOE 342 - LABORATORY IN TISSUE CULTURE

Short Title: LABORATORY IN TISSUE CULTURE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hour: 1

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 440 or STAT 440 or BIOC 311 or BIOS 311

Description: Introduction to tissue culture techniques, including cell passage, cell viability, and cell attachment and proliferation assays. Students complete quantitative analysis of their data. Engineering design and applications are featured in graded work. Sections 1 and 2 are taught during the first half of the semester. Sections 3 and 4 are taught during the second half of the semester. Students may be required to attend lab on a university holiday. Instructor Permission Required. Cross-list: BIOC 320.

BIOE 348 - MOLECULAR TECHNIQUES IN BIOENGINEERING

Short Title: MOLECULAR TECHNIQUES IN BIOE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOC 341 and (BIOE 342 (may be taken concurrently) or BIOC 320 (may be taken concurrently))

Description: Introduction to the fundamental physical principles of light interaction with matter, separation (by charge, size, confirmation) and detection techniques utilized in the field of bioengineering. These include absorbance and fluorescence spectroscopy, light and fluorescence microscopy, flow cytometry, electrophoresis, PCR, Blotting, and ELISA. BIOE 342/BIOC 320 may be taken concurrently with BIOE 348.

BIOE 360 - APPROPRIATE DESIGN FOR GLOBAL HEALTH

Short Title: APPRO DESIGN FOR GLOBAL HEALTH

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Seminar

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): GLHT 201

Description: Seminar-style introductory design course covering epidemiology, pathophysiology, health systems, health economics, medical ethics, humanitarian emergencies, scientific and engineering design methods, and appropriate health technology case studies. To register, you must be enrolled in the GLHT minor and submit a 250 statement to beyondtraditionalborders@rice.edu by Monday of preregistration. The minor and course prerequisite is waived for students majoring in Bioengineering. Instructor Permission Required. Cross-list: GLHT 360.

BIOE 361 - METABOLIC ENGINEERING FOR GLOBAL HEALTH ENVIRONMENTS

Short Title: METAB ENG GLOBAL HEALTH ENVMNT

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): (BIOE 362 or GLHT 362) and (PHYS 126 or PHYS 102 or PHYS 112 or PHYS 142) and MATH 102

Description: Importance of nutritional and pharmaceutical compounds, impact of cost of compounds on global health; Overview of biochemical pathways; metabolite analysis; Genetic engineering and molecular biology tools for ME; Pharmaceuticals and drug discovery approaches (antibiotics, antivirals; anti-parasite compounds); anti-diarrhea treatments; vaccines. Cross-list: BIOC 361, GLHT 361.

Course URL: www.btb.rice.edu

BIOE 365 - SUSTAINABLE WATER PURIFICATION FOR THE DEVELOPING WORLD

Short Title: SUST WTR PURIF FOR DEV WORLD

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Description: This course is an overview of sustainable strategies for safe water supply in off-the-grid, low-income regions. Topics covered include water quality and treatment, sustainability and WASH (water, sanitation and hygiene). A major element of the course is a project to solve a water-related issue in a real-world context. Cross-list: CEVE 314, GLHT 314. Repeatable for Credit.

BIOE 370 - BIOMATERIALS

Short Title: BIOMATERIALS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 252 and CHEM 211 and (MECH 211 (may be taken concurrently) or CEVE 211 (may be taken concurrently))

Description: This course will introduce both basic materials science and biological concepts with an emphasis on application of basic quantitative engineering principles to understanding the interactions between materials and biological systems. Topics covered include chemical structure of biomaterials, physical, mechanical, and surface properties of biomaterials, biomaterial degradation, and biomaterial processing. Additional topics include protein and cell interactions with biomaterials, biomaterial implantation, and acute inflammation, wound healing and the presence of biomaterials immune responses to biomaterials, biomaterials, immune responses to biomaterials, biomaterials and thrombosis, as well as infection, tumorigenesis, and calcification of biomaterials that can collectively apply to design of biomaterials for myriad applications. MECH 211 or CEVE 211 may be taken concurrently with BIOE 370.

BIOE 372 - BIOMECHANICS

Short Title: BIOMECHANICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 252 and MATH 212 and (MECH 211 or CEVE 211)

Description: This course introduces the fundamental principles of mechanics applied to the analysis and characterization of biological systems. Topics covered include normal and shear stresses, normal and shear strains, mechanical properties of materials, load, deformation, elasticity and elastoplastic behavior. Quantitative analysis of statically determinate and indeterminate structures subjected to tension, compression, torsion and bending will be covered. Additionally, aspects of blood rheology, viscoelasticity, and musculoskeletal mechanics will be addressed.

BIOE 380 - INTRODUCTION TO NEUROENGINEERING: MEASURING AND MANIPULATING NEURAL ACTIVITY

Short Title: INTRO TO NEUROENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): (PHYS 101 or PHYS 111 or PHYS 125 or PHYS 141) and (PHYS 102 or PHYS 112 or PHYS 126 or PHYS 142)

Description: This course will serve as an introduction to quantitative modeling of neural activity and the methods used to stimulate and record brain activity. Cross-list: ELEC 380, NEUR 383. Mutually Exclusive: Credit cannot be earned for BIOE 380 and BIOE 480/BIOE 590/ELEC 480/ELEC 580.

BIOE 381 - FUNDAMENTALS OF NERVE AND MUSCLE ELECTROPHYSIOLOGY

Short Title: FUND OF ELECTROPHYSIOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Description: An introduction to cellular electrophysiology. Includes development of whole-cell models for neurons and muscle (cardiac and skeletal muscle) cells, based on ion channel currents obtained from whole-cell voltage-clamp experiments. Material balance equations are developed for various ions and chemical signaling agents (e.g., second messengers). Numerical methods are introduced for solving the ordinary and partial differential equations associated with these models. Several types of cell models are discussed ranging from neurons and muscle cells to sensory cells of mechanoreceptors, auditory hair cells and photoreceptor cells. Volume conductor boundary-value problems frequently encountered in electrophysiology are posed. Course provides a cellular basis for the interpretation of macroscopic bioelectric signals such as the electrocardiogram (ECG), electromyogram (EMG), electroretinogram (ERG) and electroencephalogram. Cross-list: ELEC 381.

BIOE 383 - BIOMEDICAL ENGINEERING INSTRUMENTATION

Short Title: BIOMED ENGINEER INSTRUMENTTION

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): MATH 211 and ELEC 243 and (BIOC 201 or BIOS 201) and (PHYS 102 or PHYS 126 or PHYS 112)

Corequisite: BIOE 385

Description: This is an introductory level course on fundamentals of biomedical engineering instrumentation and analysis. Topics include measurement principles; fundamental concepts in electronics including circuit analysis, data acquisition, amplifiers, filters and A/D converters; Fourier analysis; temperature, pressure, and flow measurements in biological systems.

BIOE 385 - BIOMEDICAL INSTRUMENTATION LAB

Short Title: BIOMEDICAL INSTRUMENTATION LAB

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hour: 1

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Corequisite: BIOE 383

Description: Students will gain hands on experience with building biomedical instrumentation circuits and systems. Students will learn the basics of lab view programming and signal analysis. Instructor Permission Required.

BIOE 391 - NUMERICAL METHODS

Short Title: NUMERICAL METHODS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 252 and CAAM 210 and MATH 211 and MATH 212 (may be taken concurrently)

Description: Introduction to numerical approximation techniques with bioengineering applications. Topics include error propagation, Taylor's Series expansions curre fitting, roots of equations, optimization numerical differentiation and integration, ordinary differential equations, and partial differential equations. Matlab and other software will be used for solving equations. Math 212 may be taken concurrently with BIOE 391.

BIOE 392 - NEEDS FINDING AND DEVELOPMENT IN BIOENGINEERING

Short Title: NEEDS FINDING & DEV IN BIOE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Description: Students in this course will learn and develop the engineering skill of needs finding in the field of bioengineering focused on designing for disabilities. Students will work in groups with patients with disabilities to identify daily needs and develop design criteria to meet those needs including preliminary prototype development. Instructor Permission Required. Cross-list: GLHT 392.

BIOE 400 - ENGINEERING UNDERGRADUATE RESEARCH

Short Title: ENGINEERING UG RESEARCH

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Research

Credit Hours: 1-4

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Description: Independent investigation of a specific topic or problem in modern bioengineering research under the direction of a selected faculty member. Research project has a strong engineering component. Repeatable for Credit.

BIOE 401 - UNDERGRADUATE RESEARCH

Short Title: UNDERGRADUATE RESEARCH

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Research

Credit Hours: 1-4

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Description: Independent investigation of a specific topic or problem in modern bioengineering research under the direction of a selected faculty member. Repeatable for Credit.

BIOE 403 - ADVANCES IN BIONANOTECHNOLOGY

Short Title: ADVANCES IN BIONANOTECHNOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Seminar

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 370 (may be taken concurrently)

Description: This course covers nanotechnology applications in bioengineering. Students learn about cutting edge research that uses the tools of nanotechnology to tackle medical problems. Topics include bionanotechnology - related research for diagnosis, detection, and treatment of disease; cell targeting; drug design and delivery; gene therapy; prostheses and implants and tissue regeneration. (REGISTRATION NOTE: The prerequisite BIOE 370 can also be taken concurrently with BIOE 403)

BIOE 408 - SYNTHETIC BIOLOGY

Short Title: SYNTHETIC BIOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 332

Description: Design of biology at scales from molecules to multicellular organisms will be covered by lecture, primary literature, and student presentations. Students will execute a team based design challenge. Graduate/Undergraduate Equivalency: BIOE 508. Mutually Exclusive: Credit cannot be earned for BIOE 408 and BIOE 508.

BIOE 419 - INNOVATION LAB FOR MOBILE HEALTH

Short Title: INNOVATION LAB - MOBILE HEALTH

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hours: 3

Restrictions: Students with a class of Freshman may not enroll. Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Description: This course will be an innovation lab for mobile health products. The students will organize themselves in groups with complementary skills and work on a single project for the whole semester. The aim will be to develop a product prototype which can then be demonstrated to both medical practitioners and potential investors. For successful projects with an operational prototype, the next steps could be applying for OWLspark (Rice accelerator program) or crowd sourcing (like Kickstarter) and/or work in Scalable Health Labs over summer. ELEC Juniors can also continue the project outcomes as a starting point for their senior design. Cross-list: ELEC 419. Graduate/Undergraduate Equivalency: BIOE 534. Mutually Exclusive: Credit cannot be earned for BIOE 419 and BIOE 534. Repeatable for Credit.

Course URL: www.ece.rice.edu/~ashu/ELEC419.html

BIOE 420 - TRANSPORT PHENOMENA IN BIOENGINEERING

Short Title: TRANSPORT PHENOMENA IN BIOE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): MATH 211 and MATH 212 and (BIOE 332 or CHBE 411) and BIOE 391

Description: BIOE/CHBE 420 covers transport phenomena as applied to biological systems and biomedical devices. Conservation of momentum and mass equations are first derived and then used to analyze transport of momentum and mass in biology, physiology, and in biomedical devices. This course is designed for senior bioengineering students. Cross-list: CHBE 420.

BIOE 421 - MICROCONTROLLER APPLICATONS

Short Title: MICROCONTROLLER APPLICATIONS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 385

Description: This class covers the usage of microcontrollers in a laboratory setting. We will start with basic electronics and, in the lab component, design, program, and build systems utilizing widely-available microcontrollers (e.g. Arduino, Raspberry Pi). Units in motion control, sensors (light, temperature, humidity, UV/Vis absorbance), and actuation (pneumatics, gears, and motors) will provide students with functional knowledge to design and prototype their own experimental systems for laboratory-scale automation. Instructor Permission Required. Graduate/Undergraduate Equivalency: BIOE 521. Mutually Exclusive: Credit cannot be earned for BIOE 421 and BIOE 521.

BIOE 422 - GENE THERAPY

Short Title: GENE THERAPY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment limited to students with a class of Senior. Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): CHEM 211 and (BIOS 201 or BIOC 201)

Description: This course will examine the gene therapy field, with topics ranging from gene delivery to vectors to ethics of gene therapy. The design principles for engineering improved gene delivery vectors, both viral and nonviral, will be discussed. The course will culminate in a design project focused on engineering a gene delivery device for a specific therapeutic application. Graduate/Undergraduate Equivalency: BIOE 522. Mutually Exclusive: Credit cannot be earned for BIOE 422 and BIOE 522.

BIOE 431 - BIOMATERIALS APPLICATIONS

Short Title: BIOMATERIALS APPLICATIONS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): (CHEM 211 or CHEM 251) and BIOE 370

Description: Emphasis will be placed on issues regarding the design, synthesis, evaluation, regulation and clinical translation of biomaterials for specific applications. An overview of significant biomaterials engineering applications will be given, including topics such as ophthalmologic, orthopedic, cardiovascular and drug delivery applications, with attention to specific case studies. Regulatory issues concerning biomaterial will also be addressed. Assignments for this class will include frequent readings of the scientific literature with occasional homework questions, one midterm and cumulative final, a group project, a seminar report and individual presentations. Graduate/Undergraduate Equivalency: BIOE 631. Mutually Exclusive: Credit cannot be earned for BIOE 431 and BIOE 631.

BIOE 439 - APPLIED STATISTICS FOR BIOENGINEERING AND BIOTECHNOLOGY

Short Title: APPLIED STAT FOR BIOE BIOTECH

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 252 (may be taken concurrently)

Description: Course will cover fundamentals of probability and statistics with emphasis on application t biomedical problems and experimental design. Recommended for students pursuing careers in medicine or biotechnology. BIOE 439 and BIOE 440/STAT 440 cannot both be taken for credit. Prerequisite BIOE 252 may be taken concurrently. Graduate/Undergraduate Equivalency: BIOE 539. Mutually Exclusive: Credit cannot be earned for BIOE 439 and BIOE 440/BIOE 539/STAT 440.

BIOE 440 - STATISTICS FOR BIOENGINEERING

Short Title: STATISTICS FOR BIOENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hour: 1

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 252 (may be taken concurrently)

Description: Course covers application of statistics to bioengineering. Topics include descriptive statistics, estimation, hypothesis testing, ANOVA, and regression. Offered first five weeks of the semester. BIOE 252 may be taken concurrently with BIOE 440. BIOE 440/STAT 440 and BIOE 439 cannot both be taken for credit. Cross-list: STAT 440. Mutually Exclusive: Credit cannot be earned for BIOE 440 and BIOE 439.

BIOE 442 - TISSUE ENGINEERING LAB MODULE

Short Title: TISSUE ENGINEERING LAB MODULE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hour: 1

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): (BIOE 342 or BIOC 320 or BIOS 320) and (BIOE 440 or STAT 440)

Description: Students design and conduct a series of tests to synthesize PLLA, characterize PLLA and PLGA, monitor PLLA and PLGA degradation, and assess the viability, attachment, and proliferation of HDF cells on PLLA films. The experiments include many of the basic types of experiments that would be required to do a preliminary investigation of a tissue engineered product. Sections 1 and 2 will be taught during the first half of the semester and sections 3 and 4 will be taught during the second half of the semester. In addition sections 1 and 3 will need to come into lab on 2-3 Fridays and sections 2 and 4 will need to come into lab on 2-3 Saturdays. Section sign-up is required by the instructor in Keck 108 during preregistration week.

BIOE 443 - BIOPROCESSING LAB MODULE

Short Title: BIOPROCESSING LAB MODULE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hour: 1

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): (BIOE 342 or BIOC 320 or BIOS 320) and (BIOE 440 or STAT 440)

Description: Students design and conduct a series of experiments to observe the growth of E. coli under different conditions, including agar plates, shake flasks, and a small-scale bioreactor. The E. coli has been transformed with a plasmid that produces beta-galactosidase. Engineering applications are emphasized. Some work "off hours" (early evening) is required. Sections 1 and 2 are taught in the first half of the semester and Sections 3 and 4 are taught in the second half of the semester. Section sign-up is required by the instructor in Keck 108 during preregistration week.

BIOE 444 - MECHANICAL TESTING LAB MODULE

Short Title: MECHANICAL TESTING LAB MODULE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hour: 1

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 372 (may be taken concurrently) and (BIOE 440 or STAT 440)

Description: Students design and conduct a series of tests to elucidate the mechanical and material properties of animal tissue using the Instron. BIOE 372 may be taken concurrently with BIOE 444.

BIOE 445 - ADVANCED INSTRUMENTATION LAB MODULE

Short Title: ADVNCED INSTRMENTN LAB MODULE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hour: 1

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 383 and BIOE 385 and (BIOE 440 or STAT 440)

Description: Students design and build a biomedical instrumentation device. Sign up is required in Keck 108 during preregistration week.

BIOE 446 - COMPUTATIONAL MODELING LAB

Short Title: COMPUTATIONAL MODELING LAB

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hour: 1

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 391

Description: This course offers a hands-on application to systems biology modeling. Students will learn a range of modeling methods, and apply them directly in class to current bioengineering problems. Weekly tutorials will be offered, and a laptop is required (or can be loaned). Topics covered include in silico drug delivery and design studies, integrating multiscale models with high-resolution imaging, experimental design vial computer modeling, and patient-specific simulations. Modeling methods include protein-protein interaction networks, biocircuits, stochastic differential equations, agent-based modeling, computational fluid dynamics, and finite element modeling.

BIOE 447 - DIGITAL DESIGN & VISUALIZATION

Short Title: DIG DES & VIS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hour: 1

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Description: Students will acquire basic to intermediate-level digital design proficiency for bioengineering-related applications. Programs for the design of patient-specific therapies including image reconstruction, computer aided design, and parameter modeling will be used to create models. Section sign up is required during pre-registration week.

BIOE 449 - TROUBLESHOOTING WORKSHOP FOR CLINICALLY-RELEVANT BIOMEDICAL EQUIPMENT

Short Title: MED BIOENGINEERING WORKSHOP

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hour: 1

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): ELEC 243

Description: Bioengineering course in the troubleshooting, repair, and maintenance of standard biomedical equipment used in hospitals in the developed and developing worlds. Cross-list: GLHT 449. Repeatable for Credit.

BIOE 451 - BIOENGINEERING DESIGN I

Short Title: BIOENGINEERING DESIGN I

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 383 and BIOE 385 and (BIOE 332 or BIOE 372)

Description: Senior Bioengineering students will design devices in biotechnology or biomedicine. This project-based course covers systematic design processes, engineering economics, FDA requirements, safety, engineering ethics, design failures, research design, intellectual property rights, environmental impact, business planning and marketing. Students will be expected to compile documentation and present orally progress of their teams. BIOE 451 and 452 must be taken the same academic year. Instructor Permission Required.

BIOE 452 - BIOENGINEERING DESIGN II

Short Title: BIOENGINEERING DESIGN II

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 451

Description: Senior Bioengineering students will design devices in biotechnology or biomedicine. This project-based course covers systematic design processes, engineering economics, FDA requirements, safety, engineering ethics, design failures, research design, intellectual property rights, environmental impact, business planning and marketing. Students will be expected to compile documentation and present orally progress of their teams. BIOE 451 and 452 must be taken the same academic year. Instructor Permission Required.

BIOE 454 - COMPUTATIONAL FLUID MECHANICS

Short Title: COMPUTATIONAL FLUID MECHANICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): MECH 371 (may be taken concurrently) or CEVE 363 (may be taken concurrently) or CHBE 401 (may be taken concurrently)

Description: Fundamental concepts of finite element methods in fluid mechanics, including spatial discretization and numerical integration in multidimensions, time-integration, and solution of nonlinear ordinary differential equation systems. Advanced numerical stabilization techniques designed for fluid mechanics problems. Strategies for solution of complex, real-world problems. Topics in large-scale computing, parallel processing, and visualization. Prerequisites may be taken concurrently. Cross-list: CEVE 454, MECH 454. Graduate/Undergraduate Equivalency: BIOE 554. Mutually Exclusive: Credit cannot be earned for BIOE 454 and BIOE 554.

BIOE 460 - BIOCHEMICAL ENGINEERING

Short Title: BIOCHEMICAL ENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 252

Description: Design, operation, and analysis of processes in the biochemical industries. Topics include enzyme kinetics, cell growth kinetics, energetics, recombinant DNA technology, microbial, tissue and plant cell cultures, bioreactor design and operation, and down stream processing. Cross-list: CHBE 460.

BIOE 464 - EXTRACELLULAR MATRIX

Short Title: EXTRACELLULAR MATRIX

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOS 341 or BIOC 341

Description: This course will address the biology, organization, mechanics, and turnover of extracellular matrix. There will be an emphasis on cells and cell-matrix interactions, matrix distribution within and design of connective tissues and organs techniques for quantitative analysis of matrix, techniques for measurement and modeling of connective tissue biomechanics, changes with growth and aging and tissue/matrix degradation. Cross-list: BIOC 464. Graduate/Undergraduate Equivalency: BIOE 524. Recommended Prerequisite and Corequisite: BIOE 372, BIOC/BIOE 341. Mutually Exclusive: Credit cannot be earned for BIOE 464 and BIOE 524.

BIOE 470 - FROM SEQUENCE TO STRUCTURE: AN INTRODUCTION TO COMPUTATIONAL BIOLOGY

Short Title: FROM SEQUENCE TO STRUCTURE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 4

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Description: Contemporary introduction to problems in computational biology spanning sequence to structure. The course has three modules: the first introduces students to the design and statistical analysis of gene expression studies; the second covers statistical machine learning techniques for understanding experimental data generated in computational biology; and the third introduces problems in the modeling of protein structure using computational methods from robotics. The course is project oriented with an emphasis on computation and problem-solving. Cross-list: COMP 470, STAT 470. Recommended Prerequisite(s): COMP 280 and (STAT 310 or STAT 331).

BIOE 481 - COMPUTATIONAL NEUROSCIENCE AND NEURAL ENGINEERING

Short Title: COMP/NEUROSCIENCE/NEURAL ENGNR

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Description: An introduction to the anatomy and physiology of the brain. Includes basic electrophysiology of nerve and muscle. Develops mathematical models of neurons, synaptic transmission and natural neural networks. Leads to a discussion of neuromorphic circuits which can represent neuron and neural network behavior in silicon. Recommendation: Knowledge of electrical circuits, operational amplifier circuits and ordinary differential equations. Involves programming Matlab. Cross-list: ELEC 481, NEUR 481. Graduate/Undergraduate Equivalency: BIOE 583. Knowledge of basic electrical and operational amplifier circuits; and ordinary differential equations. Mutually Exclusive: Credit cannot be earned for BIOE 481 and BIOE 583.

BIOE 482 - PHYSIOLOGICAL CONTROL SYSTEMS

Short Title: PHYSIOLOGICAL CONTROL SYSTEMS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Description: A study of the somatic and autonomic nervous system control of biological systems. Simulation methods, as well as, techniques common to linear and nonlinear control theory are used. Also included is an introduction to sensors and instrumentation techniques. Examples are taken from the cardiovascular, respiratory, and visual systems. Cross-list: ELEC 482. Graduate/Undergraduate Equivalency: BIOE 582. Knowledge of basic electrical and operational amplifier circuits: and ordinary differential equations. Mutually Exclusive: Credit cannot be earned for BIOE 482 and BIOE 582.

BIOE 484 - BIOPHOTONICS INSTRUMENTATION AND APPLICATIONS

Short Title: BIOPHOTONICS INSTRUMENTATION

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 383

Description: This course is an introduction to the fundamentals of Biophotonics instrumentation related to coherent light generation, transmission by optical components such as lenses and fibers, and modulation and detection. Interference and polarization concepts and light theories including ray and wave optics will be covered. A broad variety of optical imaging and detection techniques including numerous microscopy techniques, spectral imaging, polarimetry, OCT and others will be covered. The course will guide through the principles and concepts used in a variety of optical instruments and point to special requirements for Biomedical applications with emphasis on principles and concepts used in a variety of optical instruments and point to special requirements for Biomedical applications with emphasis on principles and concepts used in a variety of optical instruments and point out special requirements for bio-medical applications in optical sensing, diagnosis, and biomedical applications. Graduate/Undergraduate Equivalency: BIOE 512. Mutually Exclusive: Credit cannot be earned for BIOE 484 and BIOE 512.

BIOE 485 - FUNDAMENTALS OF MEDICAL IMAGING I

Short Title: FUND MEDICAL IMAGING I

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Description: This course will introduce basic principles of image acquisition, formation and processing of several medical imaging modalities such as X-Ray, CT, MRI, and US that are used to evaluate the human anatomy. The course also includes visits to a clinical site to gain experience with the various imaging modalities covered in class. Cross-list: COMP 485, ELEC 485. Graduate/Undergraduate Equivalency: BIOE 591. Recommended Prerequisite(s): MATH 211 and MATH 212. Mutually Exclusive: Credit cannot be earned for BIOE 485 and BIOE 591.

BIOE 486 - FUNDAMENTALS OF MEDICAL IMAGING II

Short Title: FUND MEDICAL IMAGING II

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): ELEC 485 or BIOE 485 or COMP 485

Description: This course focuses on functional imaging modalities used specifically in nuclear medicine such as Gamma cameras, SPECT, and PET imaging. The course will introduce the basic principles of image acquisition, formation, processing and the clinical applications of these imaging modalities and lays the foundations for understanding the principles of radiotracer kinetic modeling. A trip to a clinical site in also planned to gain experience with nuclear medicine imaging. Cross-list: COMP 486, ELEC 486. Graduate/Undergraduate Equivalency: BIOE 596. Mutually Exclusive: Credit cannot be earned for BIOE 486 and BIOE 596.

BIOE 490 - INTRO COMPUTATIONAL SYSTEMS BIOLOGY: MODELING & DESIGN PRINCIPLES OF BIOCHEM NETWORKS

Short Title: INTRO SYSTEMS BIOLOGY MODELING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): (MATH 212 or MATH 213) and (BIOE 252 or CHBE 310) and BIOC 341 and CAAM 210

Description: The course summarizes techniques for quantitative analysis and simulations of basic circuits in genetic regulation, signal transduction and metabolism. We discuss engineering approaches adapted to computational systems biology and aim to formulate evolutionary design principles explaining organization of networks in terms of their physiological demands. We discuss biochemical simulation methodology and software as well as recent advances in the field. Topics include end-product inhibition in biosynthesis, optimality and robustness of the signaling networks and kinetic proofreading. Graduate/Undergraduate Equivalency: BIOE 552. Mutually Exclusive: Credit cannot be earned for BIOE 490 and BIOE 552.

BIOE 492 - SENSORY NEUROENGINEERING

Short Title: SENSORY NEUROENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Seminar

Credit Hours: 3

Restrictions: Graduate level students may not enroll.

Course Level: Undergraduate Upper-Level

Prerequisite(s): BIOE 332

Description: This course will explore how bioengineering techniques and principles are applied to understand and model sensory systems, with a focus on the auditory, vestibular, and visual systems. The interaction between the electrical, mechanical and optical aspects of these systems, and ways to modulate these interactions, will be explored. The course will also cover the design of current auditory, visual and somato-sensory neuroprosthetics (i.e. cochlear implants, retinal implants and brain-machine interfaces), as well as emerging technologies for neural stimulation. Graduate/Undergraduate Equivalency: BIOE 592. Mutually Exclusive: Credit cannot be earned for BIOE 492 and BIOE 592.

BIOE 500 - GRADUATE RESEARCH

Short Title: GRADUATE RESEARCH

Department: Bioengineering

Grade Mode: Satisfactory/Unsatisfactory

Course Type: Research

Credit Hours: 1-15

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Repeatable for Credit.

BIOE 501 - GRADUATE RESEARCH FOR MED-INTRO-GRAD PROGRAM

Short Title: GRADUATE RESEARCH

Department: Bioengineering

Grade Mode: Satisfactory/Unsatisfactory

Course Type: Research

Credit Hours: 1-6

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Graduate Research for students participating in the HHMI Med-Intro-Grad program. Med-Into-Grad students should enroll in this course during summer internship. Department approval required for enrollment. Department Permission Required. Repeatable for Credit.

BIOE 502 - PHYSICAL BIOLOGY

Short Title: PHYSICAL BIOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Basic introduction to a biophysical view of living systems, from the subcellular to the multicellular scales. Topics include: biomolecular dynamics, cellular biomechanics, cell motility and cell division, calcium signaling, action potential propagation, and tissue organization. Cross-list: SSPB 501.

BIOE 504 - FIRST YEAR GRADUATE STUDENT LAB ROTATION

Short Title: GRADUATE LAB ROTATION

Department: Bioengineering

Grade Mode: Satisfactory/Unsatisfactory

Course Type: Laboratory

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This course provides students the opportunity to experience different research projects and assists first-year students in choosing an advisor and a lab for conduction thesis research. Students must successfully complete rotations in three labs to receive a satisfactory grade. All new BIOE PhD students must take this course during their first semester.

BIOE 506 - GRADUATE INDEPENDENT STUDY

Short Title: GRADUATE INDEPENDENT STUDY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Independent Study

Credit Hours: 1-6

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Independent investigation of a specific topic in modern bioengineering research under the direction of a faculty member. Department Permission Required. Repeatable for Credit.

BIOE 507 - SYSTEMS BIOLOGY OF BLOOD VESSELS

Short Title: SYS BIOLOGY OF BLOOD VESSELS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Prerequisite(s): BIOE 252

Description: How blood vessels respond to hypoxia is a process critical to the progression of many diseases and conditions including cardiovascular disease, cancer, cerebrovascular disease, diabetes, obesity and arthritis. Physiological processes such as exercise, aging, and wound healing also depend on hypoxia-induced microvessel changes. This course introduces engineering concepts of hypoxic response, angiogenesis, and capillary remodeling - from the effects at the intracellular level to the whole body. Topics covered include computational systems biology modeling of hypoxia and angiogenesis, the use of angiogenesis in tissue engineering and regenerative medicine, imaging of blood vessel dynamics, capillaries of the brain, and the design of new blood vessels. Graduate students will be required to complete a term research project and present a related short seminar. Graduate/Undergraduate Equivalency: BIOE 307. Mutually Exclusive: Credit cannot be earned for BIOE 507 and BIOE 307.

BIOE 508 - SYNTHETIC BIOLOGY

Short Title: SYNTHETIC BIOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Design of biology at scales from molecules to multicellular organisms will be covered by lecture, primary literature, and student presentations. Students will write a research proposal at the end of the course. Cross-list: SSPB 503. Graduate/Undergraduate Equivalency: BIOE 408. Mutually Exclusive: Credit cannot be earned for BIOE 508 and BIOE 408.

BIOE 509 - POINT-OF-CARE DIAGNOSTICS

Short Title: POINT-OF-CARE DIAGNOSTICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This course provides an overview of diagnostic technologies that can be used at the point-of-care, including lateral flow assays, 2- and 3-D paper-based assays, and imaging based assays. Topics include the principles of assay design, validation and commercial development, with a focus on diagnostics for low-resource settings. The course includes a lecture and laboratory component, along with a team-based design project. Only graduate students may register for this course.

BIOE 510 - SEMINAR IN TROPICAL MEDICINE

Short Title: SEMINAR IN TROPICAL MEDICINE

Department: Bioengineering

Grade Mode: Satisfactory/Unsatisfactory

Course Type: Seminar

Credit Hour: 1

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: 8 week lecture series on topics in global health. The theme for this offering is one health; integrating efforts to obtain optimal health for humans, animals, and the environment. Offered in conjunction with the new National School of Tropical Medicine, the course will feature lectures by various experts on the public health issues most pressing in poor populations in the world today. Course open to all undergraduates and graduate students. Cross-list: GLHT 510. Repeatable for Credit.

BIOE 512 - BIOPHOTONICS INSTRUMENTATION AND APPLICATIONS

Short Title: BIOPHOTONICS INSTRUMENTATION

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This course is an introduction to the fundamentals of Biophotonics instrumentation related to coherent light generation, transmission by optical components such as lenses and fibers, and modulation and detection. Interference and polarization concepts and light theories including ray and wave optics will be covered. A broad variety of optical imaging and detection techniques including numerous microscopy techniques, spectral imaging, polarimetry, OCT and others will be covered. The course will guide through the principles and concepts used in a variety of optical instruments and point to special requirements for Biomedical applications with emphasis on principles and concepts used in a variety of optical instruments and point to special requirements for Biomedical applications with emphasis on principles and concepts used in a variety of optical instruments and point out special requirements for bio-medical applications in optical sensing, diagnosis, and biomedical applications. In addition to the undergraduate requirements in BIOE 484, graduate students will be required to complete more complex problems on both homework and tests. Graduate students will also be required to submit a research paper with oral presentations. Graduate/Undergraduate Equivalency: BIOE 484. Mutually Exclusive: Credit cannot be earned for BIOE 512 and BIOE 484.

BIOE 514 - INTRODUCTION TO BIOSTATISTICS

Short Title: INTRODUCTION TO BIOSTATISTICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 3

Restrictions: Enrollment is limited to students with a major in Bioengineering. Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Presents basic and advanced methods of statistics as applied to problems in bioengineering. Demonstrates techniques for data organization, exploration, and presentation. Foundations of statistical estimation, inference, and testing are reviewed. Optimal planning of experiments is explored. Advanced techniques include multiple regression, variable selection, logistic regression, analysis of variance, survival analysis, multiple measurements and measurements over time. Additional topics, such as Bayesian methods, will be discussed as time allows. Labs will use the statistical software JMP and/or R. Cross-list: STAT 514.

BIOE 516 - MECHANICS, TRANSPORT, AND CELLULAR SIGNALING

Short Title: MECHANICS/TRANSPORT/SIGNALING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This course will cover the fundamental principles of mechanics, thermodynamics, and transport in the context of classical and contemporary bioengineering problems. An overall goal will be to expose students to the integrated approaches that are necessary to solve complex research problems. Topics covered will include membrane transport, cell signaling, and mechanotransduction. This course is intended for first year BIOE PhD students only.

BIOE 517 - INSTRUMENTATION AND MOLECULAR ANALYSIS

Short Title: INSTRUMENT/MOLECULAR ANALYSIS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This course will cover the basic principles of optics, optical instrumentation, microscopy and molecular detection technologies. Emphasis will be placed on the application of advance microscopy techniques to imaging problems in biology and medicine. This course is intended for first year BIOE PhD students only.

BIOE 518 - INTRODUCTION TO COMPUTATIONAL BIOLOGY

Short Title: INTRO TO COMPUTATION BIOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Provides students with the ability to use computational methods to understand and analyze biological data. This course will introduce students to advances in computational cell biology from an engineering perspective, and equip them with a suite of tools emerging from systems biology. Topics covered include computational cell engineering, high-throughput analysis, modeling of signaling pathways, network analysis, imaging coupled to modeling, and multi scale modeling. This course is intended for first year BIOE PhD students only.

BIOE 519 - BIOMATERIALS SYNTHESIS

Short Title: BIOMATERIALS SYNTHESIS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Biomaterials covers the design and synthesis of materials which interact with biologic phenomena such as cell-free, microbial, and mammalian systems. Topics covered include: surfaces and surface fractionalization, biomedical implants and them immune response, three dimensional cell culture systems, and regulatory hurdles (e.g., FDA clearance). The class will be rooted in a historical perspective, with a particular emphasis on the latest techniques in synthetic chemistry relating to biomaterials. This course is intended for first year BIOE PhD students only.

BIOE 521 - MICROCONTROLLER APPLICATIONS

Short Title: MICROCONTROLLER APPLICATIONS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Prerequisite(s): BIOE 385

Description: This class covers the usage of microcontrollers in a laboratory setting. We will start with basic electronics and, in the lab component, design, program, and build systems utilizing widely-available microcontrollers (e.g. Arduino, Raspberry Pi). Units in motion control, sensors (light, temperature, humidity, UV/Vis absorbance), and actuation (pneumatics, gears, and motors) will provide students with functional knowledge to design and prototype their own experimental systems for laboratory-scale automation. BIOE 521 students will be expected to complete a final research paper. Instructor Permission Required. Graduate/Undergraduate Equivalency: BIOE 421. Mutually Exclusive: Credit cannot be earned for BIOE 521 and BIOE 421.

BIOE 522 - GENE THERAPY

Short Title: GENE THERAPY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Prerequisite(s): CHEM 212 and (BIOS 201 or BIOC 201)

Description: This course will examine the gene therapy field, with topics ranging from gene delivery to vectors to ethics of gene therapy. The design principles for engineering improved gene delivery vectors, both viral and nonviral, will be discussed. The course will culminate in a design project focused on engineering a gene delivery device for a specific therapeutic application. Graduate/Undergraduate Equivalency: BIOE 422. Mutually Exclusive: Credit cannot be earned for BIOE 522 and BIOE 422.

BIOE 523 - BIOENGINEERING SYSTEMS AND CONTROL

Short Title: BIOENG SYSTEMS & CONTROLS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Introduction to basic principles of control theory and applications of these methods and tools to analyze the dynamics of biological systems with examples from metabolic pathway control, synthetic biology and physiological systems. Cross-list: CHBE 523.

BIOE 524 - EXTRACELLULAR MATRIX

Short Title: EXTRACELLULAR MATRIC

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This course will address the biology, organization, mechanics, and turnover of extracellular matrix. There will be an emphasis on cells and cell-matrix interactions, matrix distribution within and design of connective tissues and organs techniques for quantitative analysis of matrix, techniques for measurement and modeling of connective tissue biomechanics, changes with growth and aging and tissue/matrix degradation. Additional projects will be required of graduate level students. Cross-list: BIOC 523. Graduate/Undergraduate Equivalency: BIOE 464. Recommended Prerequisite and Corequisite: BIOE 372, BIOC/BIOE 341. Mutually Exclusive: Credit cannot be earned for BIOE 524 and BIOE 464.

BIOE 525 - NANOBIOENGINEERING AND NANOMEDICINE

Short Title: NANOBIOENG AND NANOMEDICINE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Covers broad range of topics in nanobioengineering and nanomedicine, including synthesis characterization and fractionalization of nanomaterials and nanostructures, nanoparticle-based molecular imaging probes, nanocarriers, for drug/gene delivery, and nanomachines for gene editing and regulation. Examples will be given to illustrate the applications of nanobioengineering and nanomedicine.

BIOE 526 - PRECISION GENOME EDITING

Short Title: PRECISION GENOME EDITING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This is a course for graduate students who are interested in learning the emerging field of precision genome editing and its applications in biology and medicine. This is a lecture course consisting of classes that meet weekly for 3 hours; instruction is delivered both in a lecture setting and through projects.

BIOE 527 - MEDICAL TECHNOLOGY DESIGN 1

Short Title: MEDICAL TECHNOLOGY DESIGN 1

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Corequisite: BIOE 627

Description: This is the companion course to BIOE 627 and concurrent enrollment is required. Students will apply the principles learned in BIOE 627 in emerging-market design projects. Design projects are team-based, and each student will be involved in multiple projects at different levels of maturity. This course is limited to MBE-GMI students only. Instructor Permission Required.

BIOE 528 - MEDICAL TECHNOLOGY IMPLEMENTATION 1

Short Title: MEDICAL TECH IMPLEMENTATION 1

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Students focus on implementing strategies for manufacturing, regulatory, quality, and clinical trials with products that have already been through at least one cycle of design. Students are exposed to multiple projects at various levels of maturity in a team setting. This course is limited to MBE-GMI students only. Instructor Permission Required.

BIOE 529 - MEDICAL TECHNOLOGY DESIGN 2

Short Title: MEDICAL TECHNOLOGY DESIGN 2

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Corequisite: BIOE 629

Description: This is a companion course to BIOE 629 and concurrent enrollment is required. Students will apply the principles learned in BIOE 629 in emerging-market design projects. Design projects are team-based and each student will be involved in multiple projects at different levels of maturity. This course is limited to MBE-GMI students only. Instructor Permission Required.

BIOE 530 - MEDICAL TECHNOLOGY IMPLEMENTATION 2

Short Title: MEDICAL TECH IMPLEMENTATION 2

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Corequisite: BIOE 630

Description: This is the companion course to BIOE 630 and concurrent enrollment is required. Students will apply the principles learned in BIOE 630 in emerging market design projects. Design projects are team-based, and each student will be involved in multiple projects at different levels of maturity. This course is limited to MBE-BMI students only. Instructor Permission Required.

BIOE 531 - MEDICAL INNOVATION I

Short Title: MEDICAL INNOVATION I

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 3

Restrictions: Enrollment limited to students in the MBE program. Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This course will explore the front half of the medical innovation process through instruction in upstream marketing, finding and screening unmet clinical needs, and generating concepts and prototypes. Students will participate in a medical technology design project to apply the principles they are learning. Students in this course will be expected to continue their projects with BIOE 532 in the spring semester. Currently, the course is limited to MBE students. Department Permission Required.

BIOE 534 - INNOVATION LAB FOR MOBILE HEALTH

Short Title: INNOVATION LAB - MOBILE HEALTH

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This course will be an innovation lab for mobile health products. The students will organize themselves in groups with complementary skills and work on a single project for the whole semester. The aim will be to develop a product prototype which can then be demonstrated to both medical practitioners and potential investors. For successful projects with an operational prototype, the next steps could be applying for OWLspark (Rice accelerator program) or crowd sourcing (like Kickstarter) and/or work in Scalable Health Labs over summer. ELEC Juniors can also continue the project outcomes as a starting point for their senior design. Additional course work required beyond the undergraduate course requirements. Cross-list: ELEC 559. Graduate/Undergraduate Equivalency: BIOE 419. Mutually Exclusive: Credit cannot be earned for BIOE 534 and BIOE 419. Repeatable for Credit.

Course URL: www.ece.rice.edu/~ashu/ELEC419.html

BIOE 539 - APPLIED STATISTICS FOR BIOENGINEERING AND BIOTECHNOLOGY

Short Title: APPLIED STAT FOR BIOE BIOTECH

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Course will cover fundamentals of probability and statistics with emphasis on application to biomedical problems and experimental design. Recommended for students pursuing careers in medicine or biotechnology. Graduate/Undergraduate Equivalency: BIOE 439. Recommended Prerequisite(s): BIOE 252 Mutually Exclusive: Credit cannot be earned for BIOE 539 and BIOE 439.

BIOE 540 - INTRODUCTION TO SYSTEMS BIOLOGY AND SYSTEMS BIOTECHNOLOGY

Short Title: INTRO SYSTEMS BIO & BIOTECH

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Systems biology is an integrated experimental and mathematical approach to study the complex dynamic interactions between various components of a biological system. The course is designed to explore the basic concepts of systems biology. The course will introduce "systems" approaches based on genomics, transcriptomics, proteomics and metabolomics.

BIOE 543 - DNA BIOTECHNOLOGY, BIOPHYSICS, AND MODELING

Short Title: DNA BIOTECHNOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Semester-long course on fundamental properties of DNA, and their role in DNA biotechnology. Students will develop, analyze, and simulate simple biophysical models of DNA reactions, as well as learn and model methods of modern DNA biotechnology. Proficiency with MATLAB required.

BIOE 548 - MACHINE LEARNING AND SIGNAL PROCESSING FOR NEURO ENGINEERING

Short Title: NEURAL SIGNAL PROCESSING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: The activity of a complex network of billions of interconnected neurons underlies our ability to sense, represent and store the details of experienced life, and enables us to interact with our environment and other organisms. Modern neuroscience techniques enable us to access this activity, and thus to begin to understand the processes whereby individual neurons enable complex behaviors. In order to increase this understanding and to design biomedical systems which might therapeutically interact with neural circuits, advanced statistical signal processing and machine learning approaches are required. This class will cover a range of techniques and their application to basic neuroscience and neural interfaces. Topics include latent variable models, point processes, Bayesian inference, dimensionality reduction, dynamical systems, and spectral analysis. Neuroscience applications include modeling neural firing rates, spike sorting, decoding, characterization of neural systems, and field potential analysis. Cross-list: ELEC 548.

BIOE 552 - INTRO COMPUTATIONAL SYSTEMS BIOLOGY: MODELING & DESIGN PRINCIPLES OF BIOCHEM NETWORKS

Short Title: INTRO SYSTEMS BIOLOGY MODELING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: The course summarizes techniques for quantitative analysis and simulations of basic circuits in genetic regulation, signal transduction and metabolism. We discuss engineering approaches adapted to computational systems biology and aim to formulate evolutionary design principles explaining organization of networks in terms of their physiological demands. We discuss biochemical simulation methodology and software as well as recent advances in the field. Topics include end-product inhibition in biosynthesis, optimality and robustness of the signaling networks and kinetic proofreading. Same as 490 but with more emphasis on recent advances in the field - paper reading and presentations. Cross-list: SSPB 502. Graduate/Undergraduate Equivalency: BIOE 490. Basic knowledge of biochemistry, cell biology, linear algebra, and ordinary differential equations is expected. Mutually Exclusive: Credit cannot be earned for BIOE 552 and BIOE 490.

BIOE 553 - SYSTEMS BIOLOGY AND NEUROENGINEERING

Short Title: SYS BIOLOGY & NEUROENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This course will introduce students to advances in computational biology relevant to neuroengineering, and equip them with a suite of tools emerging from systems biology to student neurological processes. Example class topics include: decoding multineuron activity, models for optogenetic control, and optimization of neuro-generative therapies.

BIOE 554 - COMPUTATIONAL FLUID MECHANICS

Short Title: COMPUTATIONAL FLUID MECHANICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Prerequisite(s): MECH 371 (may be taken concurrently) or CEVE 363 (may be taken concurrently) or CHBE 401 (may be taken concurrently)

Description: Additional work required. Cross-list: CEVE 554, MECH 554. Graduate/Undergraduate Equivalency: BIOE 454. Mutually Exclusive: Credit cannot be earned for BIOE 554 and BIOE 454.

BIOE 560 - CANCER BIOLOGY

Short Title: CANCER BIOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Provides an integrated lecture series summarizing current knowledge in cancer biology and integrating current literature with basic concepts. Topics include: statistics of incidence/survival, types of cancer, pathology, the process of carcinogenesis and sources of carcinogens, genetic and epigenetic mechanisms and consequences, cancer progression, metastasis and current treatment options. Students will learn to use online databases to develop independent strategies for analyzing datasets. There will be several writing assignments and in class oral presentations of research articles. This course requires instructor permission to enroll. Please fill out the special registration form from https://registrar.rice.edu/student/special_registration. All requests will be reviewed and you will be notified of an enrollment decision. Instructor Permission Required. Cross-list: BIOC 560.

BIOE 564 - BIOINFORMATICS: NETWORK ANALYSIS

Short Title: BIOINFORMATICS: NETWORKS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This course covers computational aspects of biological network analysis, a major theme in the area of systems biology. The course addresses protein-protein interaction networks, signaling, and metabolic networks, and covers issues related to reconstructing, analyzing, and integrating various types of networks. Cross-list: BIOC 572, COMP 572.

Course URL: www.cs.rice.edu/~nakhleh/COMP572/

BIOE 574 - CONTINUUM BIOMECHANICS

Short Title: CONTINUUM BIOMECHANICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Prerequisite(s): BIOE 372

Description: This course deals with elements of continuum mechanics relevant to bioengineering. The course covers important concepts in tensor calculus, kinematics, stress and strain, and constitutive theories of continua. Selected topics in bone, articular cartilage, blood and circulation, and cell biomechanics will be discussed to illustrate the application of continuum mechanism to bioengineering problems.

BIOE 576 - FOUNDATIONS OF BIOTECHNOLOGY

Short Title: FOUNDATIONS OF BIOTECHNOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Seminar

Credit Hour: 1

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Graduate level introduction to a wide range of research methods in biosciences and bioengineering. Individual faculty members from the Biosciences and Bioengineering will each present practices and techniques for their areas of expertise. A web-based methods database will be constructed, with student involvement, from the library of lectures. Cross-list: BIOC 576.

BIOE 577 - FOUNDATIONS OF BIOTECHNOLOGY

Short Title: FOUNDATIONS OF BIOTECHNOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Seminar

Credit Hour: 1

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Graduate level introduction to a wide range of research methods in biosciences and bioengineering. Individual faculty members from the biosciences and bioengineering will each present practices and techniques for their areas of expertise. A web-based methods database will be constructed, with student involvement, from the library of lectures. Cross-list: BIOC 577.

BIOE 578 - BIOTECHNOLOGY PRACTICUM

Short Title: BIOTECHNOLOGY PRACTICUM

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Internship/Practicum

Credit Hour: 1

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This course is part of the NIH Biotechnology Training Program and is limited to program participants. Students will receive exposure and training in cutting edge concepts and technologies. Cross-list: BIOC 578.

BIOE 580 - PROTEIN ENGINEERING

Short Title: PROTEIN ENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Manipulation of gene expression in prokaryotic and eukaryotic cells. Rational design and directed evolution for cell and protein engineering. Selection and screening technologies and process optimization. Synthetic Biology: engineering and application of gene circuits. Molecular biotechnology applications: Diagnosis, Therapeutics and Vaccines. Cross-list: BIOC 580, CHBE 580. CHBE 310/510 or equivalent is highly recommended.

BIOE 581 - CARDIOVASCULAR AND RESPIRATORY SYSTEM DYNAMICS

Short Title: CARDIO - RESP SYSTEM DYNAMICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Autonomic nervous system control of the cardiovascular and respiratory systems. Development of models of neuron and cardiac cell activity; models of ventricular and vascular system mechanics; models of pulmonary mechanics and gas transport. Includes a study of instrumentation and techniques used in the cardiac catherization laboratory. Discussions of different types of ventricular assist devices is also included. The course serves as an introduction to engineering in cardiovascular and respiratory system diagnosis and critical care medicine. Cross-list: ELEC 581. Recommendation: Knowledge of ordinary differential equations; electricity and magnetism, and solid mechanics form elementary physics; linear control theory and elementary physiology of the cardiovascular and respiratory systems. Repeatable for Credit.

BIOE 582 - PHYSIOLOGICAL CONTROL SYSTEMS

Short Title: PHYSIOLOGICAL CONTROL SYSTEMS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: A study of the somatic and autonomic nervous system control of biological systems. Simulation methods, as well as, techniques common to linear and nonlinear control theory are used. Also included is an introduction to sensors and instrumentation techniques. Examples are taken from the cardiovascular, respiratory, and visual systems. Additional coursework required beyond the undergraduate course requirements. Cross-list: ELEC 582. Graduate/Undergraduate Equivalency: BIOE 482. Mutually Exclusive: Credit cannot be earned for BIOE 582 and BIOE 482.

BIOE 583 - COMPUTATIONAL NEUROSCIENCE AND NEURAL ENGINEERING

Short Title: COMP/NEUROSCIENCE/NEURAL ENGNR

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: An introduction to the anatomy and physiology of the brain. Includes basic electrophysiology of nerve and muscle. Develops mathematical models of neurons, synaptic transmission and natural neural networks. Leads to a discussion of neuromorphic circuits which can represent neuron and neural network behavior in silicon. Recommendation: Knowledge of electrical circuits, operational amplifier circuits and ordinary differential equations. Involves programming Matlab. Cross-list: ELEC 583, NEUR 583. Graduate/Undergraduate Equivalency: BIOE 481. Knowledge of basic electrical and operational amplifier circuits; and ordinary differential equations. Mutually Exclusive: Credit cannot be earned for BIOE 583 and BIOE 481.

BIOE 586 - RESPIRATORY SYSTEM MECHANICS

Short Title: RESPIRIATORY SYSTEM MECHANICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Mechanics of ventilation, respiratory muscle mechanics, rib cage mechanics, mechanical coupling between the respiratory muscles and the rib cage, and inferences on mechanics from respiratory muscle anatomy. The class will meet in the Pulmonary Division at Baylor College of Medicine in the Texas Medical Center. Cross-list: MECH 586.

BIOE 587 - OPTICAL IMAGING AND NANOBIOPHOTONICS

Short Title: OPTIC IMAGING/NANOBIOPHOTONICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This course focuses on diagnostic and therapeutic applications of photonics-based technologies with particular emphasis on nanotechnology enabled optical approaches. This course emphasizes biomedical applications of optics and complements BIOE 484 which introduces fundamental principles of optics to bioengineers.

BIOE 589 - COMPUTATIONAL MOLECULAR BIOENGINEERING/BIOPHYSICS

Short Title: COMP MOLECULAR BIOENG/BIOPHYS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This is a course designed for students in computationally-oriented biomedical and bioengineering majors to introduce the principles and methods used for the simulations and modeling of macromolecules of biological interest. Protein conformation and dynamics are emphasized. Empirical energy function and molecular dynamics calculations are described. Specific biological problems are discussed to illustrate the methodology. Classic examples such as the cooperative mechanism of hemoglobin and more frontier topics such as the motional properties of molecular motors and ion channels as well as results derived from the current literature are covered. Cross-list: BIOC 589. Recommended Prerequisite(s): MATH 212, (BIOS 301 or BIOC 301), BIOE 332.

BIOE 591 - FUNDAMENTALS OF MEDICAL IMAGING I

Short Title: FUND MEDICAL IMAGING I

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This course will introduce basic principles of image acquisition, formation and processing of several medical imaging modalities such as X-Ray, CT, MRI, and US that are used to evaluate the human anatomy. The course also includes visits to a clinical site to gain experience with the various imaging modalities covered in class. Additional coursework required beyond the undergraduate course requirements. Cross-list: ELEC 585. Graduate/Undergraduate Equivalency: BIOE 485. Mutually Exclusive: Credit cannot be earned for BIOE 591 and BIOE 485.

BIOE 592 - SENSORY NEUROENGINEERING

Short Title: SENSORY NEUROENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Seminar

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Prerequisite(s): BIOE 332 and BIOE 384

Description: This course will explore how bioengineering techniques and principles are applied to understand and model sensory systems, with a focus on the auditory, vestibular, and visual systems. The interaction between the electrical, mechanical and optical aspects of these systems, and ways to modulate these interactions, will be explored. The course will also cover the design of current auditory, visual and somato-sensory neuroprosthetics (i.e. cochlear- implants, retinal implants and brain-machine interfaces), as well as emerging technologies for neural stimulation. Graduate/Undergraduate Equivalency: BIOE 492. Mutually Exclusive: Credit cannot be earned for BIOE 592 and BIOE 492.

BIOE 595 - MODELING TISSUE MECHANICS

Short Title: MODELING TISSUE MECHANICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Independent Study

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Independent study and seminar course which focuses on modeling the mechanical properties of biological tissues. Data from experiments will be used to refine the predictions of nonlinear mathematical computer models. Aimed at juniors, seniors, and graduate students. Laboratory work performed at Baylor College of Medicine, computer work at Rice University. Cross-list: MECH 595.

BIOE 596 - FUNDAMENTALS OF MEDICAL IMAGING II

Short Title: FUND MEDICAL IMAGING II

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This course focuses on functional imaging modalities used specifically in nuclear medicine such as Gamma cameras, SPECT, and PET imaging. The course will introduce the basic principles of image acquisition, formation, processing and the clinical applications of these imaging modalities and lays the foundations for understanding the principles of radiotracer kinetic modeling. A trip to a clinical site in also planned to gain experience with nuclear medicine imaging. Additional coursework required beyond the undergraduate course requirements. Cross-list: ELEC 586. Graduate/Undergraduate Equivalency: BIOE 486. Mutually Exclusive: Credit cannot be earned for BIOE 596 and BIOE 486.

BIOE 600 - GRADUATE BIOENGINEERING INDUSTRY INTERNSHIP

Short Title: GRAD BIOE INDUSTRY INTERNSHIP

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Internship/Practicum

Credit Hours: 3-6

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Students will participate in an industry internship or industry-sponsored project under the direction of Bioengineering faculty. This course may be taken in the summer for six credits or in the fall and spring for three credits each semester. Enrollment is limited to students in the Global Medical Innovation track of the MBE degree. Instructor permission is required. Instructor Permission Required. Repeatable for Credit.

BIOE 610 - METHODS OF MOLECULAR SIMULATION

Short Title: METHODS OF MOLECULAR SIMUL

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Prerequisite(s): CHBE 611 or BIOC 589 or BIOE 589 or BIOS 589 or CHEM 520 or PHYS 526

Description: Modern simulation techniques for classical atomistic systems. Review of statistical mechanical systems. Monte Carlo and molecular dynamics simulation techniques. Extensions of the basic methods to various ensembles. Applications to simulations of large molecules such as proteins. Advanced techniques for simulation of complex systems, including constraint satisfaction, cluster moves, biased sampling, and random energy models. Cross-list: PHYS 610.

BIOE 615 - BIOENGINEERING AND CARDIAC SURGERY

Short Title: BIOENGINEERING/CARDIAC SURGERY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This course will address biomaterials and medical devices relevant to cardiac and vascular surgery and interventional cardiology in adult and pediatric patients. Mechanical and design considerations, notable successes and failures, and ethical issues will also be discussed, as will differences in cardiac disease and care due to health disparities.

BIOE 620 - TISSUE ENGINEERING

Short Title: TISSUE ENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Study of cell-cell interactions and the role of the extracellular matrix in the structure and function of normal and pathological tissues. Includes strategies to regenerate metabolic organs and repair structural tissues, as well as cell-based therapies to deliver proteins and other therapeutic drugs, with emphasis on issues related to cell and tissue transplantation such as substrate properties, angiogenesis, growth stimulation, cell differentiation, and immunoprotection. Cross-list: CHBE 620.

BIOE 621 - BIOVENTURES

Short Title: BIOVENTURES

Department: Bioengineering

Grade Mode: Satisfactory/Unsatisfactory

Course Type: Seminar

Credit Hours: 2

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Prerequisite(s): MGMT 633 or BIOE 633

Description: A hands-on immersion into life science entrepreneurship through practical lessons that are applied to students' group projects throughout the course. This practical course will provide the skills and resources to facilitate scientist-driven entrepreneurship in conceiving new life science ventures and translating research ideas into commercial ventures. This course will be taught in conjunction w/UTMB faculty on the Rice campus (BRC) and will meet from Feb 26 - April 30, 2015. To apply for the course, Rice students should fill out the online application located on the URL site listed above. Instructor Permission Required. Repeatable for Credit.

Course URL: goo.gl/forms/pJ0UMeJItO

BIOE 627 - MEDICAL TECHNOLOGY DESIGN SEMINAR 1

Short Title: MED TECH DESIGN SEMINAR 1

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 1.5

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Corequisite: BIOE 527

Description: Students will learn to discover unmet clinical needs that may benefit from a medical technology solution through disease state analysis, clinical observation, interviews, and market research. Screening of these needs will be done through market, stakeholder, competitive and intellectual property analyses. Students will participate in industry case studies and guest lectures from industry professionals. Instructor Permission Required.

BIOE 628 - MEDICAL TECHNOLOGY DESIGN SEMINAR 2

Short Title: MED TECH DESIGN SEMINAR 2

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 1.5

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Corequisite: BIOE 528

Description: Students will learn to address unmet clinical needs thru methodical design. Concept generation principles & proof-of-concept prototyping will be discussed. Screening techniques will be taught that not only weigh technical merit of a concept, but regulatory, reimbursement, IP & business strategies. Students will participate in industry case studies & guest lectures from industry professionals. Instructor Permission Required.

BIOE 631 - BIOMATERIALS APPLICATIONS

Short Title: BIOMATERIALS APPLICATIONS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Emphasis will be placed on issues regarding the design, synthesis, evaluation, regulation and clinical translation of biomaterials for specific applications. An overview of significant biomaterials engineering applications will be given, including topics such as ophthalmologic, orthopedic, cardiovascular and drug delivery applications, with attention to specific case studies. Regulatory issues concerning biomaterial will also be addressed. Assignments for this class will include frequent readings of the scientific literature with occasional homework questions, one midterm and cumulative final, a group project, a seminar report and individual presentations. In addition, graduate students in BIOE 631 will have additional exam problems and an additional research paper. Graduate/Undergraduate Equivalency: BIOE 431. Mutually Exclusive: Credit cannot be earned for BIOE 631 and BIOE 431.

BIOE 633 - LIFE SCIENCE ENTREPRENEURSHIP AND THE ROLES OF FOUNDERS AND VENTURE CAPTIAL ON HIGH TECH STARTUP

Short Title: LIFE SCIENCE ENTREPRENEURSHIP

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 1.5

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: The roles of physicians, scientists, engineers, and MBA’s in biotech, medical device, and other life science companies will be described and characterized. The major trends and innovations driving the creation of new products in large established companies and venture-capital-backed startup companies are discussed. This pragmatic, experienced-based course describes the venture capital process, formation, and capitalization of high-tech companies, sources of technologies, role of tech transfer at universities and medical schools, startup operational issues, role of VCs and board members, execution time frames, liquidity process, IPOs and mergers, and payout prospects for founders and investors. Live, ongoing case studies are presented by guest entrepreneurs. These case studies of ongoing biotech, medical device, and healthcare informatics companies are presented by many notable M.D. and Ph.D. founders and CEOs. Rules of professional and ethical conduct of M.D.s, Ph.D.s, scientific advisory boards, clinical advisory boards, and boards of directors are reviewed. In the final classes, a high-tech, career-planning guide is discussed, plus a special lecture on leadership, intelligence, and entrepreneurship will be presented. Insider secrets and success stories from decades of highly successful VC practice in medical, biotech and infotech companies will be shared. Cross-list: MGMT 633. Repeatable for Credit.

BIOE 643 - CELL MECHANICS, MECHANOTRANSDUCTION AND THE CELL MICROENVIRONMENT

Short Title: MECHANOTRANSDUCTION

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Mechanotransduction is a fundamental process essential for living systems and plays a fundamental role in cell signaling, cancer metastasis and stem cell differentiation. Additionally, fundamental biological processes such as endocytosis cell fusion and cell migration are driven by a coordinated interplay of molecular interactions that drive membrane deformation. This course will survey the current understanding of mechanotransduction and the mechanical properties of cells and their microenvironment, including membrane and cytoskeletal mechanics. Experimental approaches for measuring and manipulating the material properties of cells and their environment; including optical, electrical and magnetic techniques will be covered. A variety of application will be covered, including manipulation in engineering of mechanotransduction pathways to drive cell migration and stem cell differentiation. Instructor Permission Required. Cross-list: BIOC 643, PHYS 643.

BIOE 654 - ADVANCED COMPUTATIONAL MECHANICS

Short Title: ADV COMPUTATIONAL MECHANICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Prerequisite(s): BIOE 554 or CEVE 554 or MECH 554 or BIOE 454 or CEVE 454 or MECH 454

Description: Advanced topics in computational mechanics with emphasis on finite element methods and fluid mechanics. Stabilized formulations. Fluid-particle and fluid-structure interactions and free-surface and two-fluid flows. Interface tracking and interface-capturing techniques, space-time formulations, and mesh update methods. Enhanced discretization and solution techniques. Iterative solution methods, matrix-free computations, and advanced preconditioning techniques. Cross-list: CEVE 654, MECH 654.

BIOE 661 - ONCOLOGY FOR BIOENGINEERS: MOLECULES TO ORGANS

Short Title: ONCOLOGY FOR BIOENGINEERS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Students will develop and work through patient cases that emphasize the informational needs of graduate bioengineering students interested in cancer-related translational research. The class will review and discuss the initial case, decide on relevant learning issues, gather information, present findings for further review and discussion, and submit a case-specific written assignment. Using the same model, each student will then develop and lead his/her own patient case for class study. Instructor Permission Required. Required: Admission to Med Into Grad Program.

BIOE 680 - NANO-NEUROTECHNOLOGY

Short Title: NANO-NEUROTECHNOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Seminar

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: This course will review current nanofabricated technologies for measuring, manipulating, and controlling neural activity. The course will be based on reviewing current academic literature and topics will include nano-electronic, -photonic, -mechanical, and -fluidic neural devices. Cross-list: ELEC 680.

BIOE 682 - SYSTEMS BIOLOGY OF HUMAN DISEASES

Short Title: SYS BIO OF HUMAN DISEASES

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Introduction to concepts necessary for application of systems - Biology Approaches to Human Diseases. Topics include transcriptional and metabolic design principles, introduction to various regulatory network motifs in diseases and potential treatments using embryonic stem cells. Analysis of complex diseases using engineering concepts such as optimality, nonequilibrium thermodynamics, multiscale analysis and spatiotemporal transport. Cross-list: CHBE 682.

BIOE 690 - PROFESSIONAL DEVELOPMENT FOR BIOENGINEERS

Short Title: PROF DEVELOPMENT FOR BIOE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Professional development topics relevant to academic careers including applying for faculty positions, interviewing , negotiating offers, building a lab, obtaining funding and balancing professional obligations. Designed for graduate students planning academic careers in research-intensive bioengineering departments.

BIOE 698 - BIOENGINEERING COLLOQUIA

Short Title: BIOENGINEERING COLLOQUIA

Department: Bioengineering

Grade Mode: Satisfactory/Unsatisfactory

Course Type: Seminar

Credit Hour: 1

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Recent research in bioengineering will be presented in this colloquium series. These colloquia provide an opportunity to learn about the research at other institutions, oftentimes in an area outside students' specific dissertation specialty, and are an important part of graduate education. Graduate students in BIOE are expected to attend all regular Bioengineering colloquia. Repeatable for Credit.

BIOE 699 - BIOENGINEERING COLLOQUIA

Short Title: BIOENGINEERING COLLOQUIA

Department: Bioengineering

Grade Mode: Satisfactory/Unsatisfactory

Course Type: Seminar

Credit Hour: 1

Restrictions: Enrollment is limited to Graduate level students.

Course Level: Graduate

Description: Recent research in bioengineering will be presented in this colloquium series. These colloquia provide an opportunity to learn about the research at other institutions, oftentimes in an area outside students' specific dissertation specialty, and are an important part of graduate education. Graduate students in BIOE are expected to attend all regular Bioengineering colloquia. Repeatable for Credit.

Description and Code Legend

Note: Internally the university uses the following descriptions, codes, and abbreviations for this academic program. The following is a quick reference: 

Course Catalog/Schedule 

  • Course offerings/subject: BIOE

Department Description and Code

  • Bioengineering: BIOE

Undergraduate Degree Description and Code 

  • Bachelor of Science in Bioengineering degree: BSBE

Undergraduate Major Description and Code

  • Major in Bioengineering: BIOE 

Graduate Degree Descriptions and Codes

  • Master of Bioengineering degree: MBE
  • Master of Science degree: MS
  • Doctor of Philosophy degree: PhD

Graduate Degree Program Description and Code

  • Degree Program in Bioengineering: BIOE